Faculty of Biological Sciences
final date: Thursday, March 31, 2022
PhD supervisor: James Dillon
Co-supervisor: Catherine Denhardt
Towards an understanding of autism – a pipeline for identifying genetic variations that contribute to autism spectrum disorders and dissecting their mechanism of action
PhD descriptionIndividuals with autism have impairments in communication and social behaviour. Genes that operate across a wide range of different biological functions have been identified as being associated with an increased risk of autism. However, it is currently unclear how variation in a number of these genes leads to changes in signaling to disrupt the output of neural circuits. We have developed a pipeline using the model organism C. elegans To identify genes that coordinate social behaviour. Among these, a subset function within epigenetic and lipid signaling pathways and represent interesting targets for developing therapeutic approaches. The student will extend the existing pipeline using molecular genetic approaches, such as CRISPR, in C. elegans and mammalian neurons to introduce genetic diversity identified from human cohorts and to develop knowledge of molecular, cellular, and circulatory influences.
The project is funded for a period of 3.5 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second degree in the biological sciences or allied subjects. The funding will cover fees and provisions at current Research Council rates of £15,609 per annum for 2021/22 subject to rising for 202223.
Due to funding limitations, this position is only open to UK/EU applicants
Applications for a PhD in Biological Sciences must be submitted online at the following address:
Please put James Dillon in the field for the proposed moderator.
General inquiries should be sent to James Dillon at firstname.lastname@example.org. Any inquiries about the application process should be sent to email@example.com
Applications will be considered in the order in which they were received, and the position will be considered filled when the appropriate candidate is identified.
The University of Southampton and the School of Biological Sciences were awarded the Athena Swan Silver Award, demonstrating their commitment to providing equal opportunities and promoting the representation of women in science, technology, engineering, mathematics and medicine subjects. Due consideration will be given to applicants who have stopped working. University benefits include on-site childcare facilities, state-of-the-art on-campus sports, arts and cultural facilities, a full program of events and a range of employee discounts.